Erythropoietin and the Regulation of Erythropoiesis

IMPROVING ERYTHROPOIESIS BY HEMODIALYSIS: RELATIONSHIP WITH A DEQUACY, FREQUENCY A ND DURATION OF DIALYSIS

Serum erythropoietin (EPO) concentration was measured by an enzyme-linked immunosorbent assay (ELISA) in 31 cases of chronic renal failure (CRF), including 20 hemodialysis (HD) patients, and compared with that of 31 healthy normal controls. Each patient served as a self-control comparing his or her pretreatment level with post-treatment values. There was a significant negative correlation ...

Effects of Recombinant Human Erythropoietin (rHuEpo) on the Blood Cells and Hematopoiesis in Spleen of Rats

Recombinant human erythropoietin is a glycoprotein hormone that stimulates erythropoiesis. In clonogenic assays of hematopoietic progenitors, high concen-trations of erythropoietin (Epo) increase CFU-E and diminish the number of granulocytes formed per culture plate. Fetal progenitors are more sensitive to these effects of Epo than progenitors from adults. We administered doses 50, 100, 200 IU/...

In Vivo Regulation of Erythropoiesis by Chemically Inducible Dimerization of the Erythropoietin Receptor Intracellular Domain

Erythropoietin (Epo) and its receptor (EpoR) are required for the regulation of erythropoiesis. Epo binds to the EpoR homodimer on the surface of erythroid progenitors and erythroblasts, and positions the intracellular domains of the homodimer to be in close proximity with each other. This conformational change is sufficient for the initiation of Epo-EpoR signal transduction. Here, we establish...

Regulation of erythropoiesis. XXII. Erythropoietin production in the newborn animal.

Regulation of Erythropoiesis in the Fetus and Newborn PER

The present concept of the regulation of erythropoiesis is based on the theory that a humoral factor, erythropoietin, stimulates red cell production through its effects on the erythropoietin sensitive stem cell, on DNA synthesis in the erythroblast, and on the release of reticulocytes (Gordon and Zanjani, 1970; Hodgson, 1970). Erythropoietin production is regulated by the difference between oxy...